Innate immune modulation treating unmet medical needs
COILED’s R&D focuses on ‘Trained Immunity’, a phenomenon based on the ground-breaking research by Prof Mihai Netea, Experimental Internal Medicine at Radboudumc (Nijmegen, NL), who showed that the innate immune system has a memory. Trained immunity is the result of the DNA of the immune cells remaining in a state of high alert for several months following an infection. Epigenetic reprogramming presents the molecular basis for this process. In acknowledgement of his work, Mihai Netea was awarded the prestigious Spinoza price 2016.
Specific un(der)-explored epigenetic enzymes are targeted with small molecule inhibitors and activators to modulate innate immune memory in disease. Therapeutic focus areas include hyper-inflammation and/or immune deficiency-driven diseases like sepsis and cancer. Enzymes include histone methylases and acetylases (‘writers’) as well as histone demethylases and deacetylases (‘erasers’).